| First Author | Juhásová B | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 17 | Pages | 2709-13 |
| PubMed ID | 21820438 | Mgi Jnum | J:175998 |
| Mgi Id | MGI:5288106 | Doi | 10.1016/j.febslet.2011.07.027 |
| Citation | Juhasova B, et al. (2011) BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast. FEBS Lett 585(17):2709-13 |
| abstractText | Proteins of the Bcl-2 family regulate programmed cell death in mammals by promoting the release of cytochrome c from mitochondria in response to various proapoptotic stimuli. The mechanism by which BH3-only members of the family activate multidomain proapoptotic proteins Bax and Bak to form a pore in mitochondrial membranes remains under dispute. We report that cell death promoting activity of BH3-only protein Bim can be reconstituted in yeast when both Bax and antiapoptotic protein Bcl-X(L) are present, suggesting that Bim likely activates Bax indirectly by inhibiting antiapoptotic proteins. |
