| First Author | Akimova T | Year | 2011 |
| Journal | PLoS One | Volume | 6 |
| Issue | 8 | Pages | e24226 |
| PubMed ID | 21918685 | Mgi Jnum | J:176129 |
| Mgi Id | MGI:5288531 | Doi | 10.1371/journal.pone.0024226 |
| Citation | Akimova T, et al. (2011) Helios expression is a marker of T cell activation and proliferation. PLoS One 6(8):e24226 |
| abstractText | Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis. Over the past decade, Treg cells have become a major focus of research for many groups, and various functional subsets have been characterized. Recently, the Ikaros family member, Helios, was reported as a marker to discriminate naturally occurring, thymic-derived Tregs from those peripherally induced from naive CD4+ T cells. We investigated Helios expression in murine and human T cells under resting or activating conditions, using well-characterized molecules of naive/effector/memory phenotypes, as well as a set of Treg-associated markers. We found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. We demonstrated comparable findings using human and murine CD4+Foxp3+ Tregs, as well as in CD4+ and CD8+ T cells. Since Helios expression is associated with T cell activation and cellular division, regardless of the cell subset involved, it does not appear suitable as a marker to distinguish natural and induced Treg cells. |
