| First Author | Lipkowitz S | Year | 2011 |
| Journal | Nat Rev Cancer | Volume | 11 |
| Issue | 9 | Pages | 629-43 |
| PubMed ID | 21863050 | Mgi Jnum | J:176241 |
| Mgi Id | MGI:5289747 | Doi | 10.1038/nrc3120 |
| Citation | Lipkowitz S, et al. (2011) RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer 11(9):629-43 |
| abstractText | The ubiquitin-proteasome system has numerous crucial roles in physiology and pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases (E3s). Of these, the majority are RING finger and RING finger-related E3s. Many RING finger E3s have roles in processes that are central to the maintenance of genomic integrity and cellular homeostasis, such as the anaphase promoting complex/cyclosome (APC/C), the SKP1-cullin 1-F-box protein (SCF) E3s, MDM2, BRCA1, Fanconi anaemia proteins, CBL proteins, von Hippel-Lindau tumour suppressor (VHL) and SIAH proteins. As a result, many RING finger E3s are implicated in either the suppression or the progression of cancer. This Review summarizes current knowledge in this area. |
