| First Author | Possot C | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 10 | Pages | 949-58 |
| PubMed ID | 21909092 | Mgi Jnum | J:176650 |
| Mgi Id | MGI:5292401 | Doi | 10.1038/ni.2105 |
| Citation | Possot C, et al. (2011) Notch signaling is necessary for adult, but not fetal, development of RORgammat(+) innate lymphoid cells. Nat Immunol 12(10):949-58 |
| abstractText | The transcription factor RORgammat is required for the development of several innate lymphoid populations, such as lymphoid tissue-inducer cells (LTi cells) and cells that secrete interleukin 17 (IL-17) or IL-22. The progenitor cells as well as the developmental stages that lead to the emergence of RORgammat(+) innate lymphoid cells (ILCs) remain undefined. Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T cell potential as they successively acquired expression of the integrin alpha(4)beta(7) and CXCR6. Whereas fetal RORgammat(+) cells matured in the fetal liver environment, adult bone marrow-derived RORgammat(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner. Therefore, fetal and adult environments influence the differentiation of RORgammat(+) cells differently. |
