| First Author | Lin C | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 19 | Pages | 3120-5 |
| PubMed ID | 21907199 | Mgi Jnum | J:176651 |
| Mgi Id | MGI:5292402 | Doi | 10.1016/j.febslet.2011.08.046 |
| Citation | Lin C, et al. (2011) Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo. FEBS Lett 585(19):3120-5 |
| abstractText | Mesd is a specialized chaperone for Wnt co-receptor low-density lipoprotein receptor-related protein-5 (LRP5) and LRP6, which contain four beta-propeller/epidermal growth factor modules, named E1 to E4 from N- to C-terminal, in their extracellular domains. Herein, we demonstrated that recombinant Mesd protein is a general Wnt inhibitor that blocks Wnt/beta-catenin signaling induced not only by LRP6 E1-E2-binding Wnts but also by LRP6 E3-E4-binding Wnts. We also found that Mesd suppressed Wnt/beta-catenin signaling induced by Wnt1 in prostate cancer PC-3 cells, and inhibited tumor growth in PC-3 xenograft model. Our results indicate that Mesd is a universal inhibitor of Wnt/LRP signaling on the cell surface. |
