| First Author | Yi C | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 20 | Pages | 3303-9 |
| PubMed ID | 21945314 | Mgi Jnum | J:177346 |
| Mgi Id | MGI:5294842 | Doi | 10.1016/j.febslet.2011.09.015 |
| Citation | Yi C, et al. (2011) MiR-143 enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin. FEBS Lett 585(20):3303-9 |
| abstractText | Adipogenic differentiation of preadipocytes is a complex process regulated by various factors including miRNAs and cytokines. MiR-143 is a well known miRNA that enhances adipogenesis. Pleiotrophin (PTN), a heparin-binding growth factor, plays a negative role in adipogenesis. In this investigation, we demonstrate that PTN is a target gene of miR-143 during adipogenic differentiation in 3T3-L1 preadipocytes. MiR-143 down regulates PTN expression through interaction with a target site of miR-143 in the coding region of mouse PTN. The rare codons upstream of the target site regulate miR143-induced translational knockdown of PTN, which provides more insight into the mechanism of adipogenic differentiation. |
