| First Author | Cho SY | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 20 | Pages | 3289-96 |
| PubMed ID | 21944868 | Mgi Jnum | J:177347 |
| Mgi Id | MGI:5294843 | Doi | 10.1016/j.febslet.2011.09.012 |
| Citation | Cho SY, et al. (2011) Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. FEBS Lett 585(20):3289-96 |
| abstractText | We investigated hypocholesterolemic mechanisms of linalool, an aromatic anti-oxidative monoterpene, which is abundant in teas and essential oils. Oral administration of linalool to mice for 6weeks significantly lowered total and low-density lipoprotein cholesterol concentrations, and HMG-CoA reductase protein expression (-46%; P<0.05) by both transcriptional and posttranscriptional mechanisms. Linalool suppressed the gene expression of HMG-CoA reductase by reducing the binding of SREBP-2 to its promoter, as assessed by qPCR and chromatin immunoprecipitation, and by inducing ubiquitin-dependent proteolysis of the HMG-CoA reductase. These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms. |
