| First Author | Yim HC | Year | 2011 |
| Journal | Proc Natl Acad Sci U S A | Volume | 108 |
| Issue | 43 | Pages | 17749-54 |
| PubMed ID | 21997212 | Mgi Jnum | J:177509 |
| Mgi Id | MGI:5295326 | Doi | 10.1073/pnas.1104892108 |
| Citation | Yim HC, et al. (2011) A role for c-Myc in regulating anti-mycobacterial responses. Proc Natl Acad Sci U S A 108(43):17749-54 |
| abstractText | c-Myc (Myc) is a well known transcription factor that regulates many essential cellular processes; however, its role in modulating immunity is not known. Here, we showed different species of mycobacteria can induce Myc expression via ERK1/2 and JNK activation. Unexpectedly, the induced Myc is localized in the cytoplasm but not in the nucleus. This induced Myc expression is associated with the induction of TNF-alpha and IL-6 and with the suppression of intracellular mycobacterial growth. To delineate the underlying mechanisms, we demonstrated that Myc enhances IRAK1 degradation, leading to specific activations of ERK1/2 and p38 MAPK but not Akt, and reduces IkappaBalpha protein recovery upon degradation. Hence, our findings may provide insights into a potential role for Myc in regulating the antimicrobial responses. |
