| First Author | Sun Y | Year | 2011 |
| Journal | J Cell Sci | Volume | 124 |
| Issue | Pt 7 | Pages | 1067-76 |
| PubMed ID | 21402876 | Mgi Jnum | J:182972 |
| Mgi Id | MGI:5317252 | Doi | 10.1242/jcs.068965 |
| Citation | Sun Y, et al. (2011) Trp53 regulates Notch 4 signaling through Mdm2. J Cell Sci 124(Pt 7):1067-76 |
| abstractText | Notch receptors and their ligands have crucial roles in development and tumorigenesis. We present evidence demonstrating the existence of an antagonistic relationship between Notch 4 and Trp53, which is controlled by the Mdm2-dependent ubiquitylation and degradation of the Notch receptor. We show that this signal-controlling mechanism is mediated by physical interactions between Mdm2 and Notch 4 and suggest the existence of a trimeric complex between Trp53, Notch 4 and Mdm2, which ultimately regulates Notch activity. Functional studies indicate that Trp53 can suppress NICD4-induced anchorage-independent growth in mammary epithelial cells and present evidence showing that Trp53 has a pivotal role in the suppression of Notch-associated tumorigenesis in the mammary gland. |
