| First Author | Bartoli KM | Year | 2011 |
| Journal | Mol Biol Cell | Volume | 22 |
| Issue | 18 | Pages | 3420-30 |
| PubMed ID | 21795388 | Mgi Jnum | J:183028 |
| Mgi Id | MGI:5317365 | Doi | 10.1091/mbc.E11-03-0211 |
| Citation | Bartoli KM, et al. (2011) Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell 22(18):3420-30 |
| abstractText | The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes no longer bound to microtubules in vitro, ribosome transit rates slowed, and polysomes accumulated in intact cells, suggesting defects in elongation or termination during polypeptide synthesis. These results demonstrate that the molecular motor Eg5 associates with ribosomes and enhances the efficiency of translation. |
