| First Author | Chen AJ | Year | 2012 |
| Journal | Genes Dev | Volume | 26 |
| Issue | 13 | Pages | 1459-72 |
| PubMed ID | 22751500 | Mgi Jnum | J:185344 |
| Mgi Id | MGI:5428339 | Doi | 10.1101/gad.189001.112 |
| Citation | Chen AJ, et al. (2012) STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev 26(13):1459-72 |
| abstractText | Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI protein associates with and leads to the stabilization of miR-20a; miR-20a, in turn, regulates TGFbetaR2 and the TGFbeta signaling network. This pathway circuitry is substantiated by in silico epistasis analysis of its components in the human GBM TCGA (The Cancer Genome Atlas Project) collection and by their gain- and loss-of-function interactions in in vitro and in vivo complementation studies. This p53-QKI-miR-20a-TGFbeta pathway expands our understanding of the p53 tumor suppression network in cancer and reveals a novel tumor suppression mechanism involving regulation of specific cancer-relevant microRNAs. |
