| First Author | Hasebe A | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 16 | Pages | 2500-6 |
| PubMed ID | 22728432 | Mgi Jnum | J:186414 |
| Mgi Id | MGI:5432289 | Doi | 10.1016/j.febslet.2012.06.014 |
| Citation | Hasebe A, et al. (2012) The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1. FEBS Lett 586(16):2500-6 |
| abstractText | NELL1 is a secretory osteogenic protein containing several structural motifs that suggest that it functions as an extracellular matrix component. To determine the mechanisms underlying NELL1-induced osteoblast differentiation, we examined the cell-adhesive activity of NELL1 using a series of recombinant NELL1 proteins. We demonstrated that NELL1 promoted osteoblastic cell adhesion through at least three cell-binding domains located in the C-terminal region of NELL1. Adhesion of cells to NELL1 was strongly inhibited by function-blocking antibodies against integrin alpha3 and beta1 subunits, suggesting that osteoblastic cells adhered to NELL1 through integrin alpha3beta1. Further, focal adhesion kinase activation is involved in NELL1 signaling. |
