| First Author | Jambaldorj J | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 425 |
| Issue | 2 | Pages | 273-7 |
| PubMed ID | 22842574 | Mgi Jnum | J:187159 |
| Mgi Id | MGI:5435620 | Doi | 10.1016/j.bbrc.2012.07.081 |
| Citation | Jambaldorj J, et al. (2012) Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice. Biochem Biophys Res Commun 425(2):273-7 |
| abstractText | TATA-box binding protein associated factor 1 (TAF1) protein is the largest and the essential component of the TFIID complex in the pathway of RNA polymerase II-mediated gene transcription, and it regulates transcription of a large number of genes related to cell division. The neuron-specific isoform of the TAF1 gene (N-TAF1), which we reported previously, may have an essential role in neurons through transcriptional regulation of many neuron-specific genes. In the present study, we cloned the full-length cDNA that encodes the mouse homologue of N-TAF1 (N-Taf1) protein. By carrying out of real time RT-PCR, we investigated the expression analysis of the N-Taf1 mRNA in mouse tissues and cell lines. As well as the human N-TAF1, the N-Taf1 showed limited expression in the brain and neuroblastoma, whereas Taf1 expressed elsewhere. Furthermore, in mouse embryo head or mouse brain, mRNA expression of TAF1 changes dramatically during development but N-Taf1 showed sustained expression. Our result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis. |
