| First Author | Branitzki-Heinemann K | Year | 2012 |
| Journal | Biochem J | Volume | 446 |
| Issue | 1 | Pages | 159-63 |
| PubMed ID | 22738198 | Mgi Jnum | J:187637 |
| Mgi Id | MGI:5437575 | Doi | 10.1042/BJ20120658 |
| Citation | Branitzki-Heinemann K, et al. (2012) A novel role for the transcription factor HIF-1alpha in the formation of mast cell extracellular traps. Biochem J 446(1):159-63 |
| abstractText | MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1alpha (hypoxia-inducible factor-1alpha) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps). |
