| First Author | Ciocca ML | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 9 | Pages | 4145-8 |
| PubMed ID | 22467651 | Mgi Jnum | J:188449 |
| Mgi Id | MGI:5440561 | Doi | 10.4049/jimmunol.1200176 |
| Citation | Ciocca ML, et al. (2012) Cutting edge: Asymmetric memory T cell division in response to rechallenge. J Immunol 188(9):4145-8 |
| abstractText | Clonal selection of a T cell for use in the immune response appears to necessitate proliferative expansion and terminal effector differentiation of some cellular progeny, while reserving other progeny as less-differentiated memory cells. It has been suggested that asymmetric cell division may promote initial cell diversification. Stem cell-like models of adaptive immunity might predict that subsequent encounters with a pathogen would evoke reiterative, self-renewing, asymmetric division by memory T cells. In this study, we show that murine memory CD8(+) T cells can divide asymmetrically in response to secondary encounter with pathogen. Critical regulators of signaling and transcription are partitioned to one side of the mitotic spindle in rechallenged memory T cells, and two phenotypically distinct populations of daughter cells are evident from the earliest divisions. Memory T cells may thus use asymmetric cell division to generate cellular heterogeneity when faced with pathogen rechallenge. |
