| First Author | Ferguson TA | Year | 2012 |
| Journal | Neurosci Lett | Volume | 522 |
| Issue | 2 | Pages | 108-12 |
| PubMed ID | 22698587 | Mgi Jnum | J:188807 |
| Mgi Id | MGI:5442252 | Doi | 10.1016/j.neulet.2012.06.013 |
| Citation | Ferguson TA, et al. (2012) Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes. Neurosci Lett 522(2):108-12 |
| abstractText | We examined the neurite outgrowth of sensory neurons on astrocytes following the genetic deletion of N-cadherin (NCAD). Deletion abolished immunostaining for NCAD and the other classical cadherins, indicating that NCAD is likely the only classical cadherin expressed by astrocytes. Only 38% of neurons grown on NCAD-deficient astrocytes for 24 h produced neurites, as compared to 74% of neurons grown on NCAD-expressing astrocytes. Of the neurons that produced neurites, those grown on NCAD-deficient astrocytes had a mean total length of 378 mum, as compared to 1093 mum for neurons grown on NCAD-expressing astrocytes. Thus, the loss of NCAD greatly impairs the formation and extension neurites on astrocytes. |
