| First Author | Gong A | Year | 2012 |
| Journal | Cancer Res | Volume | 72 |
| Issue | 22 | Pages | 5658-62 |
| PubMed ID | 23139209 | Mgi Jnum | J:192025 |
| Mgi Id | MGI:5463829 | Doi | 10.1158/0008-5472.CAN-12-0953 |
| Citation | Gong A, et al. (2012) FoxM1 and Wnt/beta-catenin signaling in glioma stem cells. Cancer Res 72(22):5658-62 |
| abstractText | Cancer stem cells may be responsible for tumor initiation and maintenance. The molecular mechanisms that control cancer stem cells are related to alterations in various signaling pathways, including the Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway is one of the major signaling systems in stem and progenitor cells, and aberrant activation of the Wnt/beta-catenin signaling pathway is common in human cancers. As with beta-catenin, FoxM1 has been found to play important roles in a number of cancers. In this review, we discuss the evidence that FoxM1 affects the expression and function of a variety of genes that are critical to the survival, proliferation, invasion, angiogenesis, and self-renewal of cancer stem cells. We highlight the pivotal roles of the Wnt/beta-catenin and FoxM1 signaling pathways in neural stem and progenitor cells and glioma stem cells. We also discuss the evidence for cross-talk between the beta-catenin and FoxM1 signaling pathways in the regulation of the stemness and tumorigenicity of glioma stem cells. |
