| First Author | Kim HA | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 24 | Pages | 4296-302 |
| PubMed ID | 23137704 | Mgi Jnum | J:192239 |
| Mgi Id | MGI:5464209 | Doi | 10.1016/j.febslet.2012.10.034 |
| Citation | Kim HA, et al. (2012) PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis. FEBS Lett 586(24):4296-302 |
| abstractText | In this study, we investigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) in a platelet-activating factor (PAF)-induced experimental pulmonary tumor metastasis model. An adenovirus carrying PTEN cDNA (Ad-PTEN) reversed PAF-induced increase in phosphorylation of AKT as well as pulmonary metastasis of B16F10. PAF-induced pulmonary metastasis was inhibited by MAPK inhibitors, but not by PI3K inhibitor. Ad-PTEN abrogated PAF-induced phosphorylation of MAPKs. These data indicate PTEN/MAPK pathways play a key role in PAF-induced tumor metastasis. |
