| First Author | Subedi A | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 10 | Pages | 1556-61 |
| PubMed ID | 23597671 | Mgi Jnum | J:197357 |
| Mgi Id | MGI:5492213 | Doi | 10.1016/j.febslet.2013.03.040 |
| Citation | Subedi A, et al. (2013) Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-kappaB pathway. FEBS Lett 587(10):1556-61 |
| abstractText | MicroRNA-21 and programmed cell death 4 (PDCD4), a downstream target of miR-21, mediate diverse physiological responses. Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264.7 macrophages. These effects were abrogated by inhibitors of ERK1/2, JNK or NF-kappaB. Conditioned media collected from gAcrp-stimulated RAW 264.7 macrophages caused similar effects as direct gAcrp treatment, showing the paracrine effect of gAcrp. These data indicate that gAcrp modulates the miR-21/PDCD4 axis through the ERK and JNK/NF-kappaB pathways in RAW 264.7 macrophages and further suggest that the miR-21/PDCD4 axis may be a novel target mediating adiponectin-induced biological responses. |
