| First Author | Uribe-Herranz M | Year | 2013 |
| Journal | J Invest Dermatol | Volume | 133 |
| Issue | 6 | Pages | 1541-9 |
| PubMed ID | 23407395 | Mgi Jnum | J:198002 |
| Mgi Id | MGI:5495078 | Doi | 10.1038/jid.2012.512 |
| Citation | Uribe-Herranz M, et al. (2013) IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation. J Invest Dermatol 133(6):1541-9 |
| abstractText | Munro's microabscesses contain polymorphonuclear leukocytes and form specifically in the epidermis of psoriasis patients. The mechanism whereby the neutrophils are recruited into the epidermis is poorly understood. Using a combination of human and mouse primary keratinocyte cell cultures and the imiquimod-induced psoriasis-like mouse model of skin inflammation, we explored the role of IL-1 signaling in microabscess formation. In vitro imiquimod stimulated production of IL-1alpha and neutrophil recruiting chemokines. Imiquimod-activated chemokine expression was dependent upon adenosine signaling and independent of IL-1alpha and IL-1 receptor type 1 (IL-1R1); nevertheless, IL-1alpha could enhance chemokine expression initiated by imiquimod. Topical application of imiquimod in vivo led to epidermal microabscess formation, acanthosis, and increased IL-1alpha and chemokine expression in the skin of wild-type mice. However, in IL-1R1-deficient mice these responses were either absent or dramatically reduced. These results demonstrate that IL-1alpha and IL-1R1 signaling is essential for microabscess formation, neutrophil recruiting chemokine expression, and acanthosis in psoriasis-like skin inflammation induced by imiquimod. |
