| First Author | Yamaguchi T | Year | 2013 |
| Journal | Cancer Cell | Volume | 23 |
| Issue | 6 | Pages | 718-23 |
| PubMed ID | 23763999 | Mgi Jnum | J:199071 |
| Mgi Id | MGI:5500817 | Doi | 10.1016/j.ccr.2013.04.002 |
| Citation | Yamaguchi T, et al. (2013) NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression. Cancer Cell 23(6):718-23 |
| abstractText | Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In T cell acute lymphoblastic leukemia, gene rearrangements lead to aberrant expression of NKX2-1/TTF-1. Despite accumulating evidence supporting its oncogenic role, it has become apparent that NKX2-1/TTF-1 expression also has biological and clinical functions in the opposite direction that act against tumor progression. Herein, we review recent findings showing these enigmatic double-edged characteristics, with special attention given to the roles of NKX2-1/TTF-1 in lung development and carcinogenesis. |
