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Publication : Tet1 is required for Rb phosphorylation during G1/S phase transition.

First Author  Huang S Year  2013
Journal  Biochem Biophys Res Commun Volume  434
Issue  2 Pages  241-4
PubMed ID  23542465 Mgi Jnum  J:201210
Mgi Id  MGI:5512795 Doi  10.1016/j.bbrc.2013.02.110
Citation  Huang S, et al. (2013) Tet1 is required for Rb phosphorylation during G1/S phase transition. Biochem Biophys Res Commun 434(2):241-4
abstractText  DNA methylation plays an important role in many biological processes, including regulation of gene expression, maintenance of chromatin conformation and genomic stability. TET-family proteins convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which indicates that these enzymes may participate in DNA demethylation. The function of TET1 has not yet been well characterized in somatic cells. Here, we show that depletion of Tet1 in NIH3T3 cells inhibits cell growth. Furthermore, Tet1 knockdown blocks cyclin D1 accumulation in G1 phase, inhibits Rb phosphorylation and consequently delays entrance to G1/S phase. Taken together, this study demonstrates that Tet1 is required for cell proliferation and that this process is mediated through the Rb pathway.
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