| First Author | Hartig SM | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 434 |
| Issue | 2 | Pages | 357-62 |
| PubMed ID | 23567971 | Mgi Jnum | J:201278 |
| Mgi Id | MGI:5512923 | Doi | 10.1016/j.bbrc.2013.03.078 |
| Citation | Hartig SM, et al. (2013) Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun 434(2):357-62 |
| abstractText | Androgens regulate body composition by interacting with the androgen receptor (AR) to control gene expression in a tissue-specific manner. To identify novel regulatory roles for AR in preadipocytes, we created a 3T3-L1 cell line stably expressing human AR. We found AR expression is required for androgen-mediated inhibition of 3T3-L1 adipogenesis. This inhibition is characterized by decreased lipid accumulation, reduced expression of adipogenic genes, and induction of genes associated with osteoblast differentiation. Collectively, our results suggest androgens promote an osteogenic gene program at the expense of adipocyte differentiation. |
