| First Author | Hallenborg P | Year | 2012 |
| Journal | Cell Death Differ | Volume | 19 |
| Issue | 8 | Pages | 1381-9 |
| PubMed ID | 22388350 | Mgi Jnum | J:204629 |
| Mgi Id | MGI:5532901 | Doi | 10.1038/cdd.2012.15 |
| Citation | Hallenborg P, et al. (2012) Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. Cell Death Differ 19(8):1381-9 |
| abstractText | The role of the E3 ubiquitin ligase murine double minute 2 (Mdm2) in regulating the stability of the p53 tumor suppressor is well documented. By contrast, relatively little is known about p53-independent activities of Mdm2 and the role of Mdm2 in cellular differentiation. Here we report a novel role for Mdm2 in the initiation of adipocyte differentiation that is independent of its ability to regulate p53. We show that Mdm2 is required for cAMP-mediated induction of CCAAT/enhancer-binding protein delta (C/EBPdelta) expression by facilitating recruitment of the cAMP regulatory element-binding protein (CREB) coactivator, CREB-regulated transcription coactivator (Crtc2)/TORC2, to the c/ebpdelta promoter. Our findings reveal an unexpected role for Mdm2 in the regulation of CREB-dependent transactivation during the initiation of adipogenesis. As Mdm2 is able to promote adipogenesis in the myoblast cell line C2C12, it is conceivable that Mdm2 acts as a switch in cell fate determination. |
