| First Author | Qi Y | Year | 2014 |
| Journal | J Invest Dermatol | Volume | 134 |
| Issue | 2 | Pages | 526-537 |
| PubMed ID | 23921952 | Mgi Jnum | J:205792 |
| Mgi Id | MGI:5546459 | Doi | 10.1038/jid.2013.328 |
| Citation | Qi Y, et al. (2014) TSG-6 Released from Intradermally Injected Mesenchymal Stem Cells Accelerates Wound Healing and Reduces Tissue Fibrosis in Murine Full-Thickness Skin Wounds. J Invest Dermatol 134(2):526-37 |
| abstractText | Proper activation of macrophages (Mphi) in the inflammatory phase of acute wound healing is essential for physiological tissue repair. However, there is a strong indication that robust Mphi inflammatory responses may be causal for the fibrotic response always accompanying adult wound healing. Using a complementary approach of in vitro and in vivo studies, we here addressed the question of whether mesenchymal stem cells (MSCs)-due to their anti-inflammatory properties-would control Mphi activation and tissue fibrosis in a murine model of full-thickness skin wounds. We have shown that the tumor necrosis factor-alpha (TNF-alpha)-stimulated protein 6 (TSG-6) released from MSCs in co-culture with activated Mphi or following injection into wound margins suppressed the release of TNF-alpha from activated Mphi and concomitantly induced a switch from a high to an anti-fibrotic low transforming growth factor-beta1 (TGF-beta1)/TGF-beta3 ratio. This study provides insight into what we believe to be a previously undescribed multifaceted role of MSC-released TSG-6 in wound healing. MSC-released TSG-6 was identified to improve wound healing by limiting Mphi activation, inflammation, and fibrosis. TSG-6 and MSC-based therapies may thus qualify as promising strategies to enhance tissue repair and to prevent excessive tissue fibrosis. |
