| First Author | Bal M | Year | 2013 |
| Journal | Neuron | Volume | 80 |
| Issue | 4 | Pages | 934-46 |
| PubMed ID | 24210904 | Mgi Jnum | J:207192 |
| Mgi Id | MGI:5554645 | Doi | 10.1016/j.neuron.2013.08.024 |
| Citation | Bal M, et al. (2013) Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Neuron 80(4):934-46 |
| abstractText | Reelin is a glycoprotein that is critical for proper layering of neocortex during development as well as dynamic regulation of glutamatergic postsynaptic signaling in mature synapses. Here, we show that Reelin also acts presynaptically, resulting in robust rapid enhancement of spontaneous neurotransmitter release without affecting properties of evoked neurotransmission. This effect of Reelin requires a modest but significant increase in presynaptic Ca(2+) initiated via ApoER2 signaling. The specificity of Reelin action on spontaneous neurotransmitter release is encoded at the level of vesicular SNARE machinery as it requires VAMP7 and SNAP-25 but not synaptobrevin2, VAMP4, or vti1a. These results uncover a presynaptic regulatory pathway that utilizes the heterogeneity of synaptic vesicle-associated SNAREs and selectively augments action potential-independent neurotransmission. |
