| First Author | Kang X | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 7 | Pages | 1122-7 |
| PubMed ID | 24582795 | Mgi Jnum | J:207398 |
| Mgi Id | MGI:5556329 | Doi | 10.1016/j.febslet.2014.02.032 |
| Citation | Kang X, et al. (2014) C/EBP-alpha, involvement of a novel transcription factor in leptin-induced VCAM-1 production in mouse chondrocytes. FEBS Lett 588(7):1122-7 |
| abstractText | Leptin and vascular cell adhesion molecules-1 (VCAM-1) are two important mediators in obesity-related osteoarthritis, while the molecular mechanism linking leptin to VCAM-1 production is still obscure. Here we show that leptin upregulates VCAM-1 mRNA and protein levels in a time- and dose-dependent manner. Mechanistically, leptin induces VCAM-1 promoter activity by increasing the expression of C/EBP-alpha and facilitating its binding to a newly identified element in the VCAM-1 gene. Gain or loss of function studies reveal a regulatory role of C/EBP-alpha on VCAM-1 expression. Finally, elevated plasma leptin level correlates to increased C/EBP-alpha and VCAM-1 production in chondrocytes from obese mice. |
