| First Author | Heesters BA | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 6 | Pages | 1164-75 |
| PubMed ID | 23770227 | Mgi Jnum | J:207583 |
| Mgi Id | MGI:5559140 | Doi | 10.1016/j.immuni.2013.02.023 |
| Citation | Heesters BA, et al. (2013) Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation. Immunity 38(6):1164-75 |
| abstractText | Stromal-derived follicular dendritic cells (FDCs) are a major reservoir for antigen that are essential for formation of germinal centers, the site where memory and effector B cells differentiate. A long-standing question is how FDCs retain antigen in its native form for extended periods and how they display it to specific B cells. Here we found that FDCs acquired complement-coated immune complexes (ICs) from noncognate B cells via complement receptors 1 and 2 (CD35 and CD21, respectively) and rapidly internalized them by an actin-dependent pathway. ICs were retained intact within a nondegradative cycling compartment and were displayed periodically on the cell surface where they were accessible to antigen-specific B cells. This would explain how antigens are protected from damage and retained over long periods of time, while remaining accessible for B cells. |
