| First Author | Rigby RE | Year | 2014 |
| Journal | EMBO J | Volume | 33 |
| Issue | 6 | Pages | 542-58 |
| PubMed ID | 24514026 | Mgi Jnum | J:208040 |
| Mgi Id | MGI:5560829 | Doi | 10.1002/embj.201386117 |
| Citation | Rigby RE, et al. (2014) RNA:DNA hybrids are a novel molecular pattern sensed by TLR9. EMBO J 33(6):542-58 |
| abstractText | The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNA:DNA hybrids, as essential intracellular replication intermediates generated during infection, could therefore represent a class of previously uncharacterised pathogen-associated molecular patterns sensed by pattern recognition receptors. Here we establish that RNA:DNA hybrids containing viral-derived sequences efficiently induce pro-inflammatory cytokine and antiviral type I interferon production in dendritic cells. We demonstrate that MyD88-dependent signalling is essential for this cytokine response and identify TLR9 as a specific sensor of RNA:DNA hybrids. Hybrids therefore represent a novel molecular pattern sensed by the innate immune system and so could play an important role in host response to viruses and the pathogenesis of autoimmune disease. |
