| First Author | Mizutani T | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 9 | Pages | 1630-6 |
| PubMed ID | 24607481 | Mgi Jnum | J:208135 |
| Mgi Id | MGI:5561157 | Doi | 10.1016/j.febslet.2014.01.067 |
| Citation | Mizutani T, et al. (2014) 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts. FEBS Lett 588(9):1630-1636 |
| abstractText | In this study, we demonstrate that the 7SK small nuclear ribonucleoprotein (snRNP) complex is recruited to the HIV-1 promoter via newly-synthesized HIV-1 nascent transcripts (short transcripts) in an hnRNP A1-dependent manner and negatively regulates viral transcript elongation. Our deep-sequence analysis showed these short transcripts were mainly arrested at approximately +50 to +70 nucleotides from the transcriptional start site in the U1 cells, an HIV-1 latent model. TNF-alpha treatment promptly disrupted the 7SK snRNP complex on the nascent transcripts and viral elongated transcripts were increased. This report provides insight into how 7SK snRNP complex is recruited to HIV-1 promoter in the absence of Tat. |
