| First Author | Llobet-Navas D | Year | 2014 |
| Journal | Genes Dev | Volume | 28 |
| Issue | 7 | Pages | 765-82 |
| PubMed ID | 24636986 | Mgi Jnum | J:209596 |
| Mgi Id | MGI:5568165 | Doi | 10.1101/gad.237404.114 |
| Citation | Llobet-Navas D, et al. (2014) The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland. Genes Dev 28(7):765-82 |
| abstractText | The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, we found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. Mechanistically, we show that miR-424(322)/503 orchestrates cell life and death decisions by targeting BCL-2 and IGF1R (insulin growth factor-1 receptor). Furthermore, we demonstrate that the expression of this microRNA cluster is regulated by TGF-beta, a well-characterized regulator of mammary involution. Overall, our data suggest a model in which activation of the TGF-beta pathway after weaning induces the transcription of miR-424(322)/503, which in turn down-regulates the expression of key genes. Here, we unveil a previously unknown, multilayered regulation of epithelial tissue remodeling coordinated by the microRNA cluster miR-424(322)/503. |
