| First Author | Mu J | Year | 2014 |
| Journal | J Immunol | Volume | 192 |
| Issue | 6 | Pages | 2892-903 |
| PubMed ID | 24523508 | Mgi Jnum | J:209919 |
| Mgi Id | MGI:5568907 | Doi | 10.4049/jimmunol.1302847 |
| Citation | Mu J, et al. (2014) Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function. J Immunol 192(6):2892-903 |
| abstractText | Expression of MHC class I molecules, which provide immune surveillance against intracellular pathogens, is higher on lymphoid cells than on any other cell types. In T cells, this is a result of activation of class I transcription by the T cell enhanceosome consisting of Runx1, CBFbeta, and LEF1. We now report that MHC class I transcription in T cells also is enhanced by Foxp3, resulting in higher levels of class I in CD4(+)CD25(+) T regulatory cells than in conventional CD4(+)CD25(-) T cells. Interestingly, the effect of Foxp3 regulation of MHC class I transcription is cell type specific: Foxp3 increases MHC class I expression in T cells but represses it in epithelial tumor cells. In both cell types, Foxp3 targets the upstream IFN response element and downstream core promoter of the class I gene. Importantly, expression of MHC class I contributes to the function of CD4(+)CD25(+) T regulatory cells by enhancing immune suppression, both in in vitro and in vivo. These findings identify MHC class I genes as direct targets of Foxp3 whose expression augments regulatory T cell function. |
