| First Author | Mozzetta C | Year | 2014 |
| Journal | Mol Cell | Volume | 53 |
| Issue | 2 | Pages | 277-89 |
| PubMed ID | 24389103 | Mgi Jnum | J:213022 |
| Mgi Id | MGI:5582697 | Doi | 10.1016/j.molcel.2013.12.005 |
| Citation | Mozzetta C, et al. (2014) The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. Mol Cell 53(2):277-89 |
| abstractText | G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual interplay remains elusive. Here, we show that PRC2 and G9a/GLP interact physically and functionally. Moreover, combining different genome-wide approaches, we demonstrate that Ezh2 and G9a/GLP share an important number of common genomic targets, encoding developmental and neuronal regulators. Furthermore, we show that G9a enzymatic activity modulates PRC2 genomic recruitment to a subset of its target genes. Taken together, our findings demonstrate an unanticipated interplay between two main histone lysine methylation mechanisms, which cooperate to maintain silencing of a subset of developmental genes. |
