| First Author | Lopez M | Year | 2014 |
| Journal | J Biol Chem | Volume | 289 |
| Issue | 5 | Pages | 2736-44 |
| PubMed ID | 24337574 | Mgi Jnum | J:213039 |
| Mgi Id | MGI:5582714 | Doi | 10.1074/jbc.M113.508200 |
| Citation | Lopez M, et al. (2014) Tumor necrosis factor and transforming growth factor beta regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP). J Biol Chem 289(5):2736-44 |
| abstractText | The circadian clock drives the rhythmic expression of a broad array of genes that orchestrate metabolism, sleep wake behavior, and the immune response. Clock genes are transcriptional regulators engaged in the generation of circadian rhythms. The cold inducible RNA-binding protein (CIRBP) guarantees high amplitude expression of clock. The cytokines TNF and TGFbeta impair the expression of clock genes, namely the period genes and the proline- and acidic amino acid-rich basic leucine zipper (PAR-bZip) clock-controlled genes. Here, we show that TNF and TGFbeta impair the expression of Cirbp in fibroblasts and neuronal cells. IL-1beta, IL-6, IFNalpha, and IFNgamma do not exert such effects. Depletion of Cirbp is found to increase the susceptibility of cells to the TNF-mediated inhibition of high amplitude expression of clock genes and modulates the TNF-induced cytokine response. Our findings reveal a new mechanism of cytokine-regulated expression of clock genes. |
