| First Author | Enoki Y | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 14 | Pages | 2262-9 |
| PubMed ID | 24846137 | Mgi Jnum | J:213507 |
| Mgi Id | MGI:5585214 | Doi | 10.1016/j.febslet.2014.05.009 |
| Citation | Enoki Y, et al. (2014) Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo. FEBS Lett 588(14):2262-9 |
| abstractText | Bone is a highly vascularized organ, thus angiogenesis is a vital process during bone remodeling. However, the role of vascular systems in bone remodeling is not well recognized. Here we show that netrin-4 inhibits osteoclast differentiation in vitro and in vivo. Co-cultures of bone marrow macrophages with vascular endothelial cells markedly inhibited osteoclast differentiation. Adding a neutralizing antibody, or RNA interference against netrin-4, restored in vitro osteoclast differentiation. Administration of netrin-4 prevented bone loss in an osteoporosis mouse model by decreasing the osteoclast number. We propose that vascular endothelial cells interact with bone in suppressing bone through netrin-4. |
