| First Author | Le Pape S | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 3062-7 |
| PubMed ID | 24945730 | Mgi Jnum | J:213560 |
| Mgi Id | MGI:5585331 | Doi | 10.1016/j.febslet.2014.05.065 |
| Citation | Le Pape S, et al. (2014) Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury. FEBS Lett 588(17):3062-7 |
| abstractText | The unfolded protein response (UPR)--the endoplasmic reticulum stress response--is found in various pathologies including ischemia-reperfusion injury (IRI). However, its role during IRI is still unclear. Here, by combining two different bioinformatical methods--a method based on ordinary differential equations (Time Series Network Inference) and an algebraic method (probabilistic polynomial dynamical systems)--we identified the IRE1alpha-XBP1 and the ATF6 pathways as the main UPR effectors involved in cell's adaptation to IRI. We validated these findings experimentally by assessing the impact of their knock-out and knock-down on cell survival during IRI. |
