| First Author | Yan Z | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 3038-46 |
| PubMed ID | 24931370 | Mgi Jnum | J:213562 |
| Mgi Id | MGI:5585333 | Doi | 10.1016/j.febslet.2014.06.017 |
| Citation | Yan Z, et al. (2014) miR-96/HBP1/Wnt/beta-catenin regulatory circuitry promotes glioma growth. FEBS Lett 588(17):3038-46 |
| abstractText | We found that miR-96 is overexpressed in glioma, and its level inversely correlates with the survival of patients. The reduction in miR-96 abundance suppresses the proliferation and colony formation of glioma cells. The tumorigenicity of U-87 MG cells is reduced by miR-96 silencing. miR-96 contributes to the activation of Wnt/beta-catenin pathway in glioma cells. HMG-box transcription factor 1 (HBP-1), a Wnt/beta-catenin pathway inhibitor, is suppressed by miR-96. The reactivation of Wnt/beta-catenin signaling causes an increase in the proliferation of glioma cells, and a decrease in miR-96 expression. On the other hand, HBP1 silencing promotes miR-96 expression. Collectively, miR-96 contributes to the progression of glioma by enhancing the activation of the Wnt/beta-catenin pathway, and the miR-96/HBP1/Wnt/beta-catenin regulatory circuitry promotes the proliferation of glioma cells. |
