| First Author | Manecka DL | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 3008-14 |
| PubMed ID | 24928446 | Mgi Jnum | J:213568 |
| Mgi Id | MGI:5585339 | Doi | 10.1016/j.febslet.2014.06.009 |
| Citation | Manecka DL, et al. (2014) Inhibition of constitutive TNF production is associated with PACAP-mediated differentiation in PC12 cells. FEBS Lett 588(17):3008-14 |
| abstractText | The pituitary adenylate cyclase-activating polypeptide (PACAP) is a trophic neuropeptide that promotes cell survival and neuritogenesis in the central and peripheral nervous system. Our previous transcriptomic studies revealed the down-regulation of the cytokine tumor necrosis factor (TNF) during PACAP-induced PC12 cell differentiation. Here we show that TNF is constitutively expressed in PC12 cells in a manner dependent on NF-kappaB transcription factor, and that PACAP rapidly inhibits TNF expression and secretion. The inhibition occurs through suppression of RelB subunit of NF-kappaB, and is likely to prevent the deleterious effects of the cytokine on survival and neurite outgrowth during PC12 cell differentiation. |
