| First Author | Liu Y | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 3137-46 |
| PubMed ID | 24983504 | Mgi Jnum | J:213643 |
| Mgi Id | MGI:5585534 | Doi | 10.1016/j.febslet.2014.05.067 |
| Citation | Liu Y, et al. (2014) A feedback regulatory loop between HIF-1alpha and miR-21 in response to hypoxia in cardiomyocytes. FEBS Lett 588(17):3137-46 |
| abstractText | Accumulating evidence suggests that hypoxia-inducible factor 1alpha (HIF-1alpha) regulates numerous miRNAs and is crucial for cellular response to hypoxia. However, the relationship between HIF-1alpha and miR-21 in hypoxic cardiomyocytes is little known. We found that hypoxia induced HIF-1alpha and miR-21 expression. HIF-1alpha knockdown increased cell apoptosis and reduced miR-21 expression. Furthermore, we found that HIF-1alpha transcriptionally enhanced miR-21 promoter activity by binding to its promoter, which required the recruitment of CBP/p300. In addition, we found that miR-21 inhibition increased cell apoptosis and reduced HIF-1alpha expression, and modulated the PTEN/Akt pathway. Our results indicate that HIF-1alpha-miR-21 feedback contributes to the adaptation of cardiomyocytes to hypoxia, and has potential as therapeutic target for myocardial ischemia. |
