| First Author | Adachi K | Year | 2014 |
| Journal | Neurosci Lett | Volume | 569 |
| Pages | 49-54 | PubMed ID | 24686178 |
| Mgi Jnum | J:213651 | Mgi Id | MGI:5585542 |
| Doi | 10.1016/j.neulet.2014.03.032 | Citation | Adachi K, et al. (2014) Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Neurosci Lett 569:49-54 |
| abstractText | Mitogen-activated protein kinase phosphatase 1 (MKP-1) is shown to negatively regulate MAPK signaling in various peripheral tissues as well as the central nervous system such as cortex, striatum and hippocampus. In this study, we examined whether MKP-1 regulates MAPK signaling in the mouse hypothalamus. Intraperitoneal injection of TNFalpha significantly increased MKP-1 mRNA expression in paraventricular and arcuate nuclei in the hypothalamus. TNFalpha treatment induced increases in MKP-1 expression at both mRNA and protein levels, accompanied by the inactivation of MAPK signaling in mouse hypothalamic explants. Inhibition of MKP-1 by its inhibitor or siRNA increased MAPK activity in the explants. Our data indicate that MKP-1 negatively regulates MAPK signaling in the mouse hypothalamus. |
