| First Author | Yang L | Year | 2024 |
| Journal | Immunity | Volume | 57 |
| Issue | 5 | Pages | 1056-1070.e5 |
| PubMed ID | 38614091 | Mgi Jnum | J:347925 |
| Mgi Id | MGI:7627944 | Doi | 10.1016/j.immuni.2024.03.017 |
| Citation | Yang L, et al. (2024) Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity. Immunity |
| abstractText | A specialized population of mast cells residing within epithelial layers, currently known as intraepithelial mast cells (IEMCs), was originally observed over a century ago, yet their physiological functions have remained enigmatic. In this study, we unveil an unexpected and crucial role of IEMCs in driving gasdermin C-mediated type 2 immunity. During helminth infection, alphaEbeta7 integrin-positive IEMCs engaged in extensive intercellular crosstalk with neighboring intestinal epithelial cells (IECs). Through the action of IEMC-derived proteases, gasdermin C proteins intrinsic to the epithelial cells underwent cleavage, leading to the release of a critical type 2 cytokine, interleukin-33 (IL-33). Notably, mast cell deficiency abolished the gasdermin C-mediated immune cascade initiated by epithelium. These findings shed light on the functions of IEMCs, uncover a previously unrecognized phase of type 2 immunity involving mast cell-epithelial cell crosstalk, and advance our understanding of the cellular mechanisms underlying gasdermin C activation. |
