| First Author | Wilk CM | Year | 2013 |
| Journal | Exp Hematol | Volume | 41 |
| Issue | 9 | Pages | 823-831.e2 |
| PubMed ID | 23660069 | Mgi Jnum | J:215436 |
| Mgi Id | MGI:5605259 | Doi | 10.1016/j.exphem.2013.04.010 |
| Citation | Wilk CM, et al. (2013) The tissue inhibitor of metalloproteinases-1 improves migration and adhesion of hematopoietic stem and progenitor cells. Exp Hematol 41(9):823-831.e2 |
| abstractText | Homing and engraftment of hematopoietic stem and progenitor cells (HSPCs) during bone marrow transplantation are critically dependent on integrins such as beta1-integrin. In the present study, we show that beta1-integrin and the tetraspanin CD63 form a cell surface receptor complex for the soluble serum protein tissue inhibitor of metalloproteinases-1 (TIMP-1) on human CD34(+) HSPCs. Through binding to this receptor complex, TIMP-1 activates beta1-integrin, increases adhesion and migration of human CD34(+) cells, and protects these cells from induced apoptosis. TIMP-1 stimulation in murine bone marrow mononuclear cells also promotes migration and adhesion; this is associated with augmented homing of murine mononuclear cells and of murine LSK(+) cells during bone marrow transplantation. These results not only indicate that TIMP-1 is conducive to HSPC homing; they also identify CD63 and beta1-integrin as a TIMP-1 receptor complex on HSPCs. |
