| First Author | Huang A | Year | 2014 |
| Journal | Exp Cell Res | Volume | 326 |
| Issue | 2 | Pages | 259-66 |
| PubMed ID | 24780820 | Mgi Jnum | J:217141 |
| Mgi Id | MGI:5613105 | Doi | 10.1016/j.yexcr.2014.04.010 |
| Citation | Huang A, et al. (2014) miR-34a expands myeloid-derived suppressor cells via apoptosis inhibition. Exp Cell Res 326(2):259-66 |
| abstractText | Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population and show significant expansion under pathological conditions. microRNA plays important roles in many biological processes, whether microRNAs have a function in the expansion of MDSCs is still not very clear. In this study, miR-34a overexpression can induce the expansion of MDSCs in bone marrow chimera and transgenic mice model. The experimental results suggest that miR-34a inhibited the apoptosis of MDSCs but did not affect the proliferation of MDSCs. The distinct mRNA microarray profiles of MDSCs of wild type and miR-34a over-expressing MDSCs combined with the target prediction of miR-34a suggest that miR-34a may target genes such as p2rx7, Tia1, and plekhf1 to inhibit the apoptosis of MDSCs. Taken together, miR-34a contributes to the expansion of MDSCs by inhibiting the apoptosis of MDSCs. |
