| First Author | Zeng M | Year | 2014 |
| Journal | Science | Volume | 346 |
| Issue | 6216 | Pages | 1486-92 |
| PubMed ID | 25525240 | Mgi Jnum | J:217372 |
| Mgi Id | MGI:5613819 | Doi | 10.1126/science.346.6216.1486 |
| Citation | Zeng M, et al. (2014) MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. (Retracted). Science 346(6216):1486-92 |
| abstractText | Multivalent molecules with repetitive structures including bacterial capsular polysaccharides and viral capsids elicit antibody responses through B cell receptor (BCR) crosslinking in the absence of T cell help. We report that immunization with these T cell-independent type 2 (TI-2) antigens causes up-regulation of endogenous retrovirus (ERV) RNAs in antigen-specific mouse B cells. These RNAs are detected via a mitochondrial antiviral signaling protein (MAVS)-dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production. Deficiency of both MAVS and cGAS, or treatment of MAVS-deficient mice with reverse transcriptase inhibitors, dramatically inhibits TI-2 antibody responses. These findings suggest that ERV and two innate sensing pathways that detect them are integral components of the TI-2 B cell signaling apparatus. |
