| First Author | Bremm A | Year | 2014 |
| Journal | EMBO Rep | Volume | 15 |
| Issue | 12 | Pages | 1268-77 |
| PubMed ID | 25355043 | Mgi Jnum | J:217543 |
| Mgi Id | MGI:5614519 | Doi | 10.15252/embr.201438850 |
| Citation | Bremm A, et al. (2014) Cezanne (OTUD7B) regulates HIF-1alpha homeostasis in a proteasome-independent manner. EMBO Rep 15(12):1268-77 |
| abstractText | The transcription factor HIF-1alpha is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1alpha is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1alpha homeostasis. Loss of Cezanne decreases HIF-1alpha target gene expression due to a reduction in HIF-1alpha protein levels. Surprisingly, although the Cezanne-regulated degradation of HIF-1alpha depends on the tumour suppressor pVHL, hydroxylase and proteasome activity are dispensable. Our data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy. |
