| First Author | Giusti SA | Year | 2014 |
| Journal | Elife | Volume | 3 |
| PubMed ID | 25406064 | Mgi Jnum | J:218201 |
| Mgi Id | MGI:5616977 | Doi | 10.7554/eLife.02755 |
| Citation | Giusti SA, et al. (2014) MicroRNA-9 controls dendritic development by targeting REST. Elife 3 |
| abstractText | MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth. |
