| First Author | Rubin MA | Year | 2014 |
| Journal | Cancer Discov | Volume | 4 |
| Issue | 11 | Pages | 1262-4 |
| PubMed ID | 25367948 | Mgi Jnum | J:218263 |
| Mgi Id | MGI:5617093 | Doi | 10.1158/2159-8290.CD-14-1075 |
| Citation | Rubin MA (2014) Insights into the mechanism of organ-specific cancer metastasis. Cancer Discov 4(11):1262-4 |
| abstractText | SUMMARY: Lucas and colleagues nominate transmembrane serine protease type II (TMPRSS2) as an important player in the initiation of epithelial-mesenchymal transition (EMT) in prostate cancer. Cancer cells maintain androgen receptor-regulated cytoplasmic TMPRSS2 expression, which facilitates EMT invasion and metastasis in model systems through hepatocyte growth factor and c-MET signaling. In addition to providing a rationale for potentially targeting this organ-specific enabler of metastatic disease progression, this study also highlights the importance of understanding how organ/tissue-specific genes are co-opted in the context of cancer. |
