| First Author | Takahashi S | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 7 | Pages | 829-35 |
| PubMed ID | 25724334 | Mgi Jnum | J:220236 |
| Mgi Id | MGI:5634020 | Doi | 10.1016/j.febslet.2015.02.016 |
| Citation | Takahashi S, et al. (2015) C-type lectin-like domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen. FEBS Lett 589(7):829-35 |
| abstractText | Phospholipase A2 receptor 1 (PLA2R) mediates collagen-dependent migration. The mechanisms by which PLA2R interacts with collagen remain unclear. We produced HEK293 cells expressing full-length wild-type PLA2R or a truncated PLA2R that lacks fibronectin-like type II (FNII) domains or several regions of C-type lectin-like domain (CTLD). We show that the CTLD1-2 as well as the FNII domain of PLA2R are responsible for binding to collagen and for collagen-dependent migration. Thus, multiple regions and domains of the extracellular portion of PLA2R participate in the responses to collagen. These data suggest a potentially new mechanism for PLA2R-mediated biological response beyond that of a receptor for secretory PLA2. |
