| First Author | Park S | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 458 |
| Issue | 1 | Pages | 134-9 |
| PubMed ID | 25637539 | Mgi Jnum | J:220378 |
| Mgi Id | MGI:5634595 | Doi | 10.1016/j.bbrc.2015.01.082 |
| Citation | Park S, et al. (2015) Regulation of retinoid X receptor gamma expression by fed state in mouse liver. Biochem Biophys Res Commun 458(1):134-9 |
| abstractText | Glucose metabolism is balanced by glycolysis and gluconeogenesis with precise control in the liver. The expression of genes related to glucose metabolism is regulated primarily by glucose and insulin at transcriptional level. Nuclear receptors play important roles in regulating the gene expression of glucose metabolism at transcriptional level. Some of these nuclear receptors form heterodimers with RXRs to bind to their specific regulatory elements on the target promoters. To date, three isotypes of RXRs have been identified; RXRalpha, RXRbeta and RXRgamma. However, their involvement in the interactions with other nuclear receptors in the liver remains unclear. In this study, we found RXRgamma is rapidly induced after feeding in the mouse liver, indicating a potential role of RXRgamma in controlling glucose or lipid metabolism in the fasting-feeding cycle. In addition, RXRgamma expression was upregulated by glucose in primary hepatocytes. This implies that glucose metabolism governed by RXRgamma in conjunction with other nuclear receptors. The luciferase reporter assay showed that RXRgamma as well as RXRalpha increased SREBP-1c promoter activity in hepatocytes. These results suggest that RXRgamma may play an important role in tight control of glucose metabolism in the fasting-feeding cycle. |
