| First Author | Yamaguchi N | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 12 | Pages | 1369-75 |
| PubMed ID | 25911380 | Mgi Jnum | J:221416 |
| Mgi Id | MGI:5639148 | Doi | 10.1016/j.febslet.2015.04.022 |
| Citation | Yamaguchi N, et al. (2015) The seventh zinc finger motif of A20 is required for the suppression of TNF-alpha-induced apoptosis. FEBS Lett 589(12):1369-75 |
| abstractText | The ubiquitin-editing enzyme A20 suppresses nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in a deubiquitinating and ubiquitin ligase activity-dependent manner. Although recent studies revealed that A20 regulates NF-kappaB independently of its enzymatic activity through its seventh zinc finger motif (ZnF7), the involvement of ZnF7 in TNF-alpha-induced apoptosis is not clear. In this study, ZnF7 was found to be important for A20-mediated suppression of TNF-alpha-induced apoptosis. We also found that the ubiquitin ligases cIAP1/2 are required for A20 to suppress TNF-alpha-induced apoptosis. Because A20 binds to cIAP1/2 through ZnF7, these results suggest that A20 may control cIAP1/2 when suppressing TNF-alpha-induced apoptosis. |
